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Publications
Publications
- “DNA methylation directs functional maturation of pancreatic beta cells”. Dhawan, S., Tschen, S.I., Zeng, C., Guo, T., Hebrok, M., Matveyenko, A., Bhushan, A. J Clin Invest. 2015 June 125(125(7):2851–2860):2851–2860.
- "The histone demethylase Jmjd3 sequentially associates with the transcription factors Tbx3 and eomes to drive endoderm differentiation." Kartikasari AE, Zhou JX, Kanji MS, Chan DN, Sinha A, Grapin-Botton A, Magnuson MA, Lowry WE, Bhushan A.EMBO J. 2013 May 15;32(10):1393-408. |PubMed
- "Dicer1 is required to repress neuronal fate during endocrine cell maturation." Kanji MS, Martin MG, Bhushan A.Diabetes. 2013 May;62(5):1602-11. | PubMed
- "DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis." Georgia S, Kanji M, Bhushan A.Genes Dev. 2013 Feb 15;27(4):372-7. | PubMed
- "Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming." Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L.Genes Dev. 2011 Nov 1;25(21):2291-305. | PDF | PubMed
- "Skp2 is required for incretin hormone-mediated beta-cell proliferation." Tschen SI, Georgia S, Dhawan S, Bhushan A.Mol Endocrinol. 2011 Dec;25(12):2134-43. | PDF | PubMed
- "Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx." Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A.Dev Cell. 2011 Apr 19;20(4):419-29. | PDF | PubMed
- "Inconsistent formation and nonfunction of insulin-positive cells from pancreatic endoderm derived from human embryonic stem cells in athymic nude rats." Matveyenko AV, Georgia S, Bhushan A, Butler PC.Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E713-20. | PDF | PubMed
- "Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents." Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN. Diabetes. 2010 Apr;59(4):987-96.. | PDF | PubMed
- "Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation." Dhawan S, Tschen SI, Bhushan A. Genes Dev. 2009 Apr 15;23(8):906-11. | PDF | PubMed
- "Age-dependent Decline in Beta Cell Proliferation Restricts the Capacity of Beta Cell Regeneration in Mice." Tschen SI, Dhawan S, Gurlo T, Bhushan A. Diabetes. 2009 Jun;58(6):1312-20. Epub 2009 Feb 19. | PDF | PubMed
- "Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass." Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K. PLoS ONE. 2009;4(2):e4394, Epub 2009 Feb 6. | PDF | PubMed
- "Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans." Meier JJ, Butler AE, Saisho Y, Monchamp T, Galasso R, Bhushan A, Rizza RA, Butler PC. Diabetes. 2008 Jun;57(6):1584-94, Epub 2008 Mar 11. | PDF | PubMed
- "Formation and regeneration of the endocrine pancreas." Dhawan S, Georgia S, Bhushan A.
Curr Opin Cell Biol. 2007 Dec;19(6):634-45, Epub 2007 Dec 3. Review. | PDF | PubMed
- "The replication of beta cells in normal physiology, in disease and for therapy." Butler PC, Meier JJ, Butler AE, Bhushan A. Nat Clin Pract Endocrinol Metab. 2007 Nov;3(11):758-68, Review. | PubMed
- "Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells." Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. J Clin Invest. 2007 Oct;117(10):2869-76. |PDF | PubMed
- "Hematopoietic stem cells derived from adult donors are not a source of pancreatic beta-cells in adult nondiabetic humans." Butler AE, Huang A, Rao PN, Bhushan A, Hogan WJ, Rizza RA, Butler PC. Diabetes. 2007 Jul;56(7):1810-6, Epub 2007 Apr 24. | PDF | PubMed
- "p27 Regulates the transition of beta-cells from quiescence to proliferation." Georgia S, Bhushan A. Diabetes. 2006 Nov;55(11):2950-6. | PDF | PubMed
- "p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors." Georgia S, Soliz R, Li M, Zhang P, Bhushan A. Dev Biol. 2006 Oct 1;298(1):22-31, Epub 2006 Jun 2. | PDF | PubMed
- "The potential for stem cell therapy in diabetes." Meier JJ, Bhushan A, Butler PC.Pediatr Res. 2006 Apr;59(4 Pt 2):65R-73R, Review. | PDF | PubMed
- "Formation of pancreatic duct epithelium from bone marrow during neonatal development." Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A, Crooks GM. Stem Cells. 2006 Feb;24(2):307-14. | PDF | PubMed
- "Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?" Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Diabetologia. 2005 Nov;48(11):2221-8, Epub 2005 Oct 5. | PDF | PubMed
- "Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass." Georgia S, Bhushan A. J Clin Invest. 2004 Oct;114(7):963-8. | PDF | PubMed
- "Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis." Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R.Development. 2001 Dec;128(24):5109-17. | PDF | PubMed
- "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex." Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG. Nat Genet. 1999 Aug;22(4):394-9. | PDF | PubMed
- "Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos." Bhushan A, Chen Y, Vale W. Dev Biol. 1998 Aug 15;200(2):260-8. | PDF | PubMed
- "Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase." Chen Y, Bhushan A, Vale W.Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12938-43. Erratum in: Proc Natl Acad Sci U S A 1998 Feb 17;95(4):1968. |PDF | PubMed
- "The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm." Bhushan A, Lin HY, Lodish HF, Kintner CR. Mol Cell Biol. 1994 Jun;14(6):4280-5. | PDF | PubMed